Perioperative blood transfusion and the prognosis of ovarian cancer surgery: A meta-analysis
Abstract
Background and Objective: Perioperative blood transfusion (PBT) is a common procedure in ovarian cancer (OC) surgery, which may be a deleterious prognosis predictor. Therefore, this study aimed to assess the impact of PBT on survival indicators in OC patients using meta-analysis.
Methods: This study was performed in adherence to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. Relevant articles were collected by searching the PubMed, Embase, Google Scholar, and Cochrane Library databases up to September 30, 2024. A random-effects model was used to calculate pooled hazard ratios (HRs). Sensitivity analysis, sub-analysis, and publication bias were evaluated.
Results: This study included nine studies, including 3,727 OC patients. 53.4% of the patients received transfusions. Overall, PBT was associated with shorter overall survival (OS), with pooled HRs of 1.44 (95% CI 1.21–1.71; P < 0.001, I2 = 60.4%) and 1.55 (95% CI 1.17–2.06; P < 0.001, I2 = 79.5%) for OS and progression-free survival (PFS), respectively. This result was also obtained using sensitivity analysis. Subgroup analysis revealed the greater impact of PBT on OS in the early OC stage than in the late stage.
Conclusions: The patients receiving PBT exhibited lower survival after OC surgery, and this impact was more pronounced in early-stage patients.
doi: https://doi.org/10.12669/pjms.41.6.11293
How to cite this: Huang QY, Huang YX, Mu WY, Li PC. Perioperative blood transfusion and the prognosis of ovarian cancer surgery: A meta-analysis. Pak J Med Sci. 2025;41(6):1818-1825. doi: https://doi.org/10.12669/pjms.41.6.11293
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
